The series revolves around the thoracic surgery department of a hospital.
Park Tae Soo is a thoracic surgery fellow for four years whose mother is waiting for a heart transplant. Meanwhile, Choi Suk Han is a thoracic surgeon who is renowned for his skills but has not been treated fairly due to his humble medical background from a local university.
A mysterious woman, who had a near death experience, decides to become a resident of thoracic surgery.

In Joseon Dynasty, immaculately dressed in scholarly robes, the young nobleman Kim Sung Yeol lives as a vampire to keep his promise to his friends. When Sung Yeol still was a human, he found out about the vampire Gwi who sits above the King deciding the next royal line and has resurrected as a vampire trying to fight against Gwi. And now, he is living as a guardian vampire fighting against the evil vampire without losing his human nature.

Joo Joong Won is the stingy and greedy CEO of Kingdom, a conglomerate that includes a major department store and hotel. He meets the gloomy Tae Gong Shil, who started seeing ghosts after an accident. Their lives take a new turn as they work together to deal with the terror and sadness brought about by the spirits, while delving into a kidnapping incident in Joong Won's past. And unknowingly, they fell in love with each other.