Tearjerkers

the leads separate

ML vanishes/dies?

FL dies

the leads separate

FL is terminally ill

ML has only a few years left to live

ML dies, FL ends up with the SML, so could be seen as bittersweet

the leads separate

FL becomes mentally ill and trapped in her life

ML is terminally ill, all three leads appear still as lost at the end as at the beginning

the leads separate

ML is either dead or critically wounded at the end, it's unclear

ML dies

one of the MLs dies, other is terminally ill

FL dies

both leads die

FL dies

ML dies

the leads are separated by time (FL returns to the present, ML remains in the past)

the leads are separated (FL returns to the real world, ML remains in the fictional one)

ML dies

FL dies, ML is prevented from adopting/raising her child who he was attached to

FL dies

ML dies

FL and supporting characters die

ML dies

ML and other supporting characters die

leads separate

FL dies

one of the FLs dies

both leads die

the leads are separated by timelines that run backwards from each other (FL dies in one part of the timeline)

FL dies (possibly ML as well, it's unclear)

FL dies

ML dies

the leads separate (ML returns to the past, FL stays in present day)

the leads separate (FL returns to the past, ML stays in the present)

the leads separate (they exist in opposite moving timelines (early meetings for one are later for the other) and die in different times)

the leads separate

FL dies

both leads die

the leads separate (it appears one may die) 

FL dies

the leads are separated (ML returns to the past, FL stays in the present)

ML dies

FL dies

FL dies

ML dies

ML dies