The first dramas that popped up on my head were: (and they are my most favourites dramas ever ever!)
Wait my youth
My Girl (2020)
Actually what I loved the most about the first one (year 2019) was exactly what you are asking for, the lead only has eyes for her and he is so sure she's the one. I was so in love with the couple, I was so sure they were dating in real life otherwise nothing on Earth would make sense! haha. 1000% chemistry. Wait my youth is a coming of age drama, starts on high school.
After just finishing that drama, news came up that that the same actors would be leading their second drama together (I was so so happy, but I was worried the drama wouldn't meet my expectations). i waited for a year and it literally became the best drama ever for me. Their chemistry was on another level and everything (plot, characters, ost, etc.) was just perfect! This was a more mature drama comparing to the last one, and the male lead also only has eyes for her since the beggining. There is not things such as female/male second leads.
Hope you give it a try to those dramas someday so we can fangirl together! :)